Aug 10, 2021 · On the Horizon. As we enter the decade of the 2020s, a new group of medications will be proposed for the treatment of Alzheimer’s Disease. Unlike their predecessors, these are considered to be “disease-modifying” medications capable of altering the course of Alzheimer’s Disease’s progression. The first of these, aducanumab, currently ... January 06, 2023. Today, the U.S. Food and Drug Administration approved Leqembi (lecanemab-irmb) via the Accelerated Approval pathway for the treatment of Alzheimer’s disease. Leqembi is the ...The medication memantine (Namenda), for instance, may help people with later-stage Alzheimer’s maintain the ability to use the bathroom independently for several extra months. ( 2 )Aug 25, 2021 · Allow the medicine a few weeks to take effect. It is recommended that people with Alzheimer's should NOT take anticholinergic drugs. These drugs are used to treat many medical problems such as sleeping problems, stomach cramps, incontinence, asthma, motion sickness, and muscle spasms. Side effects, such as confusion, can be serious for a person ... There is currently no cure for Alzheimer’s disease. As well as medications, there are non-drug interventions that aim to delay the loss of mental abilities, to help people stay independent in everyday life for as long as possible, and to increase their wellbeing and quality of life.Examples of medications used to treat sleep changes include: Tricyclic antidepressants, such as nortriptyline. Benzodiazepines, such as lorazepam, oxazepam and temazepam. “Sleeping pills” such as zolpidem, zaleplon and chloral hydrate. “Atypical” antipsychotics such as risperidone, olanzapine and quetiapine.Drugs to treat the cognitive symptoms of dementia A number of drugs are currently available in Australia for use by people with dementia. These drugs fall into two categories, cholinergic treatments and Memantine. Cholinergic Cholinergic treatments offer some relief from the symptoms of Alzheimer’s disease for some people for a limited time.Even though the chief cause of behavioral symptoms is the effect of Alzheimer's disease on the brain, an examination may reveal other treatable conditions that are contributing to the behavior. Contributing conditions may include: Drug side effects. Many people with Alzheimer's take prescription medications for other health issues.Jun 7, 2021 · The Food and Drug Administration on Monday approved Biogen ’s Alzheimer’s disease drug aducanumab, making it the first medication cleared by U.S. regulators to slow cognitive decline in people ... Jun 1, 2020 · Whether you’re caring for someone with Alzheimer’s disease or another dementia diagnosis, medication can help keep individuals calm and reduce their stress and anxiety. Let’s take a closer look at the different types of drugs that are used in Alzheimer’s care and other dementia cases. Preventing Pain Jan 6, 2020 · Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Presently, the drugs available for AD treatment, including cholinesterase inhibitors and an antagonist of the N-methyl-D-aspartate receptor, can only inhibit dementia symptoms for a limited ... In the early stages of Alzheimer's, the person with dementia may need help remembering to take medications. As a caregiver, you may find it helpful to: Use a pill box organizer. Using a pill box or keeping a daily list or calendar can help ensure medication is taken as prescribed. Develop a routine for giving the medication.The development and approval of Leqembi, the first FDA-approved medication proven to slow the progression of Alzheimer’s disease, is a milestone. But there is a need to develop drugs with ...Drug approval process for the treatment of Alzheimer’s disease. Alzheimer Society of Canada. Get the full picture of how a drug gets approved for public use in Canada, including a list of the currently approved medications that can treat the symptoms of Alzheimer's. Treatment options. Alzheimer Society of Canada.There is currently no cure for Alzheimer’s disease. As well as medications, there are non-drug interventions that aim to delay the loss of mental abilities, to help people stay independent in everyday life for as long as possible, and to increase their wellbeing and quality of life.Non-drug approaches to changes in mood and behaviour. It is common for people with dementia to develop changes in mood and behaviour. In most cases, with the right person-centred care and support, these changes will pass. Non-drug approaches that should always be tried first. Read more. May 12, 2023 · Reminyl ER ™ (brand name) or Galantamine (generic name) Exelon ™ (brand name) or Rivastigmine (generic name) Ebixa® (brand name) or Memantine (generic name) For the purpose of your treatment, it doesn't matter whether the medication is brand name or generic – their effects are the same. Depending on how severe your symptoms are and how ... People with Alzheimer’s disease may become agitated or aggressive as the disease gets worse. Agitation means that a person is restless or worried. He or she doesn’t seem to be able to settle down. Agitation may cause pacing, sleeplessness, or aggression, which is when a person lashes out verbally or tries to hit or hurt someone.The side effects usually get better after 2 weeks of taking the medication. Memantine. This medicine is not an AChE inhibitor. It works by blocking the effects of an excessive amount of a chemical in the brain called glutamate. Memantine is used for moderate or severe Alzheimer's disease. It's suitable for those who cannot take or are unable to ... There may not be an obvious cause. But many times, there are triggers you can spot before or during a problem. Common ones include: Discomfort from lack of sleep, side effects from medication, or ...Common Namzaric side effects may include: nausea, vomiting, diarrhea, loss of appetite; headache; dizziness; or. easy bruising. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Namzaric side effects.Jan 6, 2023 · Jan. 6, 2023. The Food and Drug Administration on Friday approved a new Alzheimer’s drug that may modestly slow the pace of cognitive decline early in the disease, but also carries risks of ... Oct 8, 2021 · Alzheimer disease (AD) is a neurodegenerative disorder of uncertain cause and pathogenesis that primarily affects older adults and is the most common cause of dementia [ 1 ]. The most essential and often earliest clinical manifestation of AD is selective memory impairment, although there are exceptions. While treatments are available that can ... As a result of FDA’s approval of Aduhelm, patients with Alzheimer’s disease have an important and critical new treatment to help combat this disease. FDA will continue to monitor Aduhelm as it ...Alzheimer disease is the most common form of dementia, affecting more than one-third of Americans older than 85 years. It is characterized by progressive memory loss and cognitive decline. Amyloid ...The FDA has approved medications that fall into two categories: drugs that change disease progression in people living with early Alzheimer's disease, and drugs that may temporarily mitigate some symptoms of Alzheimer's dementia.Aducanumab (Aduhelm®) has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration (FDA). Aducanumab was the first therapy to demonstrate that removing beta-amyloid, one of the hallmarks of Alzheimer’s disease, from the brain reduces cognitive and functional decline in people living ...Drugs that temporarily ease some symptoms of Alzheimer's disease. Drugs that change disease progression in people living with Alzheimer's. When thinking about any treatment, it is important to have a conversation with a health care professional to determine whether it is appropriate. Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.Jan 6, 2023 · According to the company's phase 3 trial data, about 12.6 % of patients who received the medication experienced brain swelling, compared with just 1.7% of those in the placebo group.About 17% of ... Get a copy Order by post. There are four medications approved in the UK to ease a person’s dementia symptoms, including memory and thinking problems: donepezil. rivastigmine. galantamine. memantine. These treatments are only effective for people with Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, and mixed ... June 07, 2021. Today, the U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was ...Antipsychotic medications can treat dementia symptoms such as aggression or psychosis. But these drugs can cause serious side effects. ... Alzheimer’s disease is the most common form of dementia ...Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.There are three types of cholinesterase inhibitor medications currently approved and prescribed to treat Alzheimer's disease: Aricept (donepezil): Approved for mild, moderate, and severe Alzheimer's. Exelon (rivastigmine): Approved for mild to moderate Alzheimer's. Razadyne (galantamine): Approved for mild to moderate Alzheimer's.Aug 19, 2023 · There are three types of cholinesterase inhibitor medications currently approved and prescribed to treat Alzheimer's disease: Aricept (donepezil): Approved for mild, moderate, and severe Alzheimer's. Exelon (rivastigmine): Approved for mild to moderate Alzheimer's. Razadyne (galantamine): Approved for mild to moderate Alzheimer's. Alzheimer's and dementia medications – overview of cholinesterase inhibitors (Aricept, Exelon, ... The truth is that medications are available that may help treat symptoms. Although these drugs don’t work for everyone, they offer some hope for the more than 6 million people who have AD. Treatment for mild to moderate Alzheimer’s disease. There are three FDA-approved drugs available to treat symptoms due to mild to moderate AD.Recently, the U.S. Food and Drug Administration (FDA) approved a new prescription medication for Alzheimer’s disease. Get answers to some commonly asked questions about Aduhelm, the first treatment to be approved in over 18 years for this devastating disease affecting 6.2 million Americans.Oct 12, 2021 · Learn about prescription drugs and other strategies to treat the symptoms of Alzheimer's disease. Find out about medicines to avoid and take with caution. Return to top There are three drugs of this type: donepezil ( Aricept ), galantamine ( Razadyne ), and rivastigmine ( Exelon ). Aricept is the only treatment approved by the FDA for all stages of Alzheimer’s ... Huperzine A. Huperzine A (pronounced HOOP-ur-zeen) is a moss extract that has been used in traditional Chinese medicine for centuries. It has properties similar to those of cholinesterase inhibitors, one class of FDA-approved Alzheimer's medications. As a result, it is promoted as a treatment for Alzheimer's disease. The development and approval of Leqembi, the first FDA-approved medication proven to slow the progression of Alzheimer’s disease, is a milestone. But there is a need to develop drugs with ...Jun 7, 2021 · Drugmaker reverses course, plans to seek FDA approval for Alzheimer's treatment. In July 2020, Biogen completed its submission to the FDA for a Biologics License Application for approval of the drug. Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.Alzheimer disease most commonly affects older adults, but it can also affect people in their 30s or 40s. When Alzheimer disease occurs in someone under age 65, it is known as early-onset (or younger-onset) Alzheimer disease. A very small number of people with Alzheimer disease have the early-onset form. Many of them are in their 40s and 50s ...Huperzine A. Huperzine A (pronounced HOOP-ur-zeen) is a moss extract that has been used in traditional Chinese medicine for centuries. It has properties similar to those of cholinesterase inhibitors, one class of FDA-approved Alzheimer's medications. As a result, it is promoted as a treatment for Alzheimer's disease.Jun 28, 2022 · In June 2021, the FDA granted accelerated approval for Aduhelm — the name-brand form of the medication aducanumab — to treat mild Alzheimer's-related dementia. But due to its high cost and concerns over its benefits and risks, doctors and healthcare systems have been hesitant to offer this medication. Keep up with coverage decisions with GoodRx. Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.June 07, 2021. Today, the U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was ...The truth is that medications are available that may help treat symptoms. Although these drugs don’t work for everyone, they offer some hope for the more than 6 million people who have AD. Treatment for mild to moderate Alzheimer’s disease. There are three FDA-approved drugs available to treat symptoms due to mild to moderate AD. Jul 6, 2023 · The Food and Drug Administration on Thursday fully approved the Alzheimer’s drug Leqembi, amid concerns about its safety, cost and accessibility. The move marks the first time that a drug meant ... The side effects usually get better after 2 weeks of taking the medication. Memantine. This medicine is not an AChE inhibitor. It works by blocking the effects of an excessive amount of a chemical in the brain called glutamate. Memantine is used for moderate or severe Alzheimer's disease. It's suitable for those who cannot take or are unable to ...The side effects usually get better after 2 weeks of taking the medication. Memantine. This medicine is not an AChE inhibitor. It works by blocking the effects of an excessive amount of a chemical in the brain called glutamate. Memantine is used for moderate or severe Alzheimer's disease. It's suitable for those who cannot take or are unable to ...May 17, 2017 · People with Alzheimer’s disease may become agitated or aggressive as the disease gets worse. Agitation means that a person is restless or worried. He or she doesn’t seem to be able to settle down. Agitation may cause pacing, sleeplessness, or aggression, which is when a person lashes out verbally or tries to hit or hurt someone. These medicines include: Donepezil ( Aricept) Galantamine ( Razadyne, Razadyne ER, Reminyl) Rivastigmine ( Exelon) What to expect: Most people with Alzheimer’s who take one of these medications ...Tests Diagnosing Alzheimer's disease would likely include the following tests: Physical and neurological exam A health care professional will perform a physical exam. A neurological exam may include testing: Reflexes. Muscle tone and strength. Ability to get up from a chair and walk across the room. Sense of sight and hearing. Coordination.Aug 30, 2023 · Strategies aimed at beta-amyloid include: Recruiting the immune system. Medicines known as monoclonal antibodies may prevent beta-amyloid from clumping into plaques. They also may remove ... Preventing destruction. A medicine initially developed as a possible cancer treatment — saracatinib — is now ... Drug approval process for the treatment of Alzheimer’s disease. Alzheimer Society of Canada. Get the full picture of how a drug gets approved for public use in Canada, including a list of the currently approved medications that can treat the symptoms of Alzheimer's. Treatment options. Alzheimer Society of Canada.The cholinesterase inhibitors are the main first-line treatment for Alzheimer’s disease. These drugs attempt to make up for depleted levels of acetylcholine. For moderate to severe disease, doctors often add the NMDA receptor drug. Researchers are still exploring the exact role of the new MAB drug. Aducanumab (Aduhelm) is a MAB and is the ...Jul 25, 2022 · Medications are one option. Adlarity (donepezil patches) and Aduhelm (aducanumab) have made headlines recently, but several other medications treat Alzheimer’s-related dementia. A 30-day supply of donepezil tablets, the most common medication for Alzheimer’s-related dementia, costs as low as $4 with a free GoodRx coupon. Recently, the U.S. Food and Drug Administration (FDA) approved a new prescription medication for Alzheimer’s disease. Get answers to some commonly asked questions about Aduhelm, the first treatment to be approved in over 18 years for this devastating disease affecting 6.2 million Americans.The Food and Drug Administration (FDA) recently granted full approval to a new Alzheimer’s treatment called lecanemab, which has been shown to moderately slow cognitive and functional decline in early-stage cases of the disease. Alzheimer’s disease is a progressive disorder that damages and destroys nerve cells in the brain. Over time, the ...Evidence Summary. A 2018 meta-analysis examining medications used to alleviate agitation in all types of dementia included 36 RCTs with a total of 5,585 participants (mean age = 81.8 years ± 4.9 ...Galantamine (Razadyne): This drug is used to prevent or slow the symptoms of mild to moderate AD. It comes as a tablet, extended-release capsule, or oral solution (liquid). Memantine (Namenda ...FDA-approved drugs for Alzheimer's. The U.S. Food and Drug Administration (FDA) has approved medications that fall into two categories: drugs that change disease progression in people living with Alzheimer’s, and drugs that may temporarily mitigate some symptoms of the disease. Treatments may be available in different forms (pill, patch or ... Common Namzaric side effects may include: nausea, vomiting, diarrhea, loss of appetite; headache; dizziness; or. easy bruising. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Namzaric side effects.Jun 1, 2020 · Whether you’re caring for someone with Alzheimer’s disease or another dementia diagnosis, medication can help keep individuals calm and reduce their stress and anxiety. Let’s take a closer look at the different types of drugs that are used in Alzheimer’s care and other dementia cases. Preventing Pain Tests Diagnosing Alzheimer's disease would likely include the following tests: Physical and neurological exam A health care professional will perform a physical exam. A neurological exam may include testing: Reflexes. Muscle tone and strength. Ability to get up from a chair and walk across the room. Sense of sight and hearing. Coordination.Aug 10, 2021 · On the Horizon. As we enter the decade of the 2020s, a new group of medications will be proposed for the treatment of Alzheimer’s Disease. Unlike their predecessors, these are considered to be “disease-modifying” medications capable of altering the course of Alzheimer’s Disease’s progression. The first of these, aducanumab, currently ... This can help keep a person with dementia on track regarding taking the correct medications. The Alzheimer’s Association states that doctors may prescribe lorazepam and oxazepam to treat anxiety ...Jun 7, 2021 · Drugmaker reverses course, plans to seek FDA approval for Alzheimer's treatment. In July 2020, Biogen completed its submission to the FDA for a Biologics License Application for approval of the drug. The FDA has approved medications that fall into two categories: drugs that change disease progression in people living with early Alzheimer's disease, and drugs that may temporarily mitigate some symptoms of Alzheimer's dementia.There are three types of cholinesterase inhibitor medications currently approved and prescribed to treat Alzheimer's disease: Aricept (donepezil): Approved for mild, moderate, and severe Alzheimer's. Exelon (rivastigmine): Approved for mild to moderate Alzheimer's. Razadyne (galantamine): Approved for mild to moderate Alzheimer's.Oct 12, 2021 · Learn about prescription drugs and other strategies to treat the symptoms of Alzheimer's disease. Find out about medicines to avoid and take with caution. Return to top Aducanumab (Aduhelm®) has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration (FDA). Aducanumab was the first therapy to demonstrate that removing beta-amyloid, one of the hallmarks of Alzheimer’s disease, from the brain reduces cognitive and functional decline in people living ...On the Horizon. As we enter the decade of the 2020s, a new group of medications will be proposed for the treatment of Alzheimer’s Disease. Unlike their predecessors, these are considered to be “disease-modifying” medications capable of altering the course of Alzheimer’s Disease’s progression. The first of these, aducanumab, currently ...Jul 17, 2023 · Patients in the early stages of Alzheimer's may soon have a new option to stave off the loss of memory and thinking. In a study of more than 1,700 people, the experimental drug donanemab slowed ... Drugs that temporarily ease some symptoms of Alzheimer's disease. Drugs that change disease progression in people living with Alzheimer's. When thinking about any treatment, it is important to have a conversation with a health care professional to determine whether it is appropriate. Fig 1. Aetiology of Alzheimer's disease with therapeutic targets. A – secretase enzyme inhibitors; B – NMDA receptor modulators, eg memantine; C – immunotherapy, including immunisation and direct anti-amyloid therapy, including monoclonal antibodies; D – anti-tau therapy; E – anti-inflammatory treatments, including NSAIDs; F ...The FDA has approved medications that fall into two categories: drugs that change disease progression in people living with early Alzheimer's disease, and drugs that may temporarily mitigate some symptoms of Alzheimer's dementia.Jul 6, 2023 · The Food and Drug Administration on Thursday fully approved the Alzheimer’s drug Leqembi, amid concerns about its safety, cost and accessibility. The move marks the first time that a drug meant ...
Jan 6, 2023 · Jan. 6, 2023. The Food and Drug Administration on Friday approved a new Alzheimer’s drug that may modestly slow the pace of cognitive decline early in the disease, but also carries risks of ... . Cemiplimab rwlc
There may not be an obvious cause. But many times, there are triggers you can spot before or during a problem. Common ones include: Discomfort from lack of sleep, side effects from medication, or ...Examples of medications used to treat sleep changes include: Tricyclic antidepressants, such as nortriptyline. Benzodiazepines, such as lorazepam, oxazepam and temazepam. “Sleeping pills” such as zolpidem, zaleplon and chloral hydrate. “Atypical” antipsychotics such as risperidone, olanzapine and quetiapine. Broad Medicare coverage of Leqembi and similar types of medications to slow the progression of Alzheimer’s disease will probably have a big impact on the program’s spending.Lecanemab is an investigational drug for the treatment of Alzheimer’s disease developed jointly by pharmaceutical companies Eisai and Biogen. Lecanemab is a type of drug called a monoclonal ...Medications. The following are used to temporarily improve dementia symptoms. Cholinesterase inhibitors. These medicines work by boosting levels of a chemical messenger involved in memory and judgment. They include donepezil (Aricept, Adlarity), rivastigmine (Exelon) and galantamine (Razadyne ER).Tests Diagnosing Alzheimer's disease would likely include the following tests: Physical and neurological exam A health care professional will perform a physical exam. A neurological exam may include testing: Reflexes. Muscle tone and strength. Ability to get up from a chair and walk across the room. Sense of sight and hearing. Coordination.Jan 6, 2023 · Jan. 6, 2023. The Food and Drug Administration on Friday approved a new Alzheimer’s drug that may modestly slow the pace of cognitive decline early in the disease, but also carries risks of ... Jan 6, 2020 · Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Presently, the drugs available for AD treatment, including cholinesterase inhibitors and an antagonist of the N-methyl-D-aspartate receptor, can only inhibit dementia symptoms for a limited ... Aug 11, 2023 · Usual Adult Dose for Alzheimer's Disease: Initial dose: 5 mg orally once a day, in the evening prior to retiring Mild to moderate Alzheimer's disease:-Maintenance dose: 10 mg orally once a day, after the patient has been on an initial dose of 5 mg once a day for 4 to 6 weeks Moderate to severe Alzheimer's disease: Alzheimer disease most commonly affects older adults, but it can also affect people in their 30s or 40s. When Alzheimer disease occurs in someone under age 65, it is known as early-onset (or younger-onset) Alzheimer disease. A very small number of people with Alzheimer disease have the early-onset form. Many of them are in their 40s and 50s ...Simplify medications. Justify every medication; Eliminate redundancies and duplications; Pharmacies can blister-pack medications for easy identification and compliance; Reduction in drug passes may reduce errors and caregiver or care partner burden; Pharmacological treatment. Current medications cannot cure Alzheimer’s disease. Strategies aimed at beta-amyloid include: Recruiting the immune system. Medicines known as monoclonal antibodies may prevent beta-amyloid from clumping into plaques. They also may remove beta-amyloid plaques that have formed. They do this by helping the body clear them from the brain.Medication to treat depression in Alzheimer's There are several types of antidepressants available to treat depression. Antidepressants called Selective Serotonin Reuptake Inhibitors (SSRIs) are often used for people with Alzheimer's and depression because they have a lower risk than some other antidepressants of causing interactions with other ... Antipsychotic medications can treat dementia symptoms such as aggression or psychosis. But these drugs can cause serious side effects. ... Alzheimer’s disease is the most common form of dementia ...All of the already established treatments that are used today try to counterbalance the neurotransmitter imbalance of the disease. The acetylocholinesterase inhibitors (AChEIs) which are approved for the treatment of AD are donepezil, galantamine, and rivastigmine. 4,5 Their development was based in the cholinergic hypothesis which suggests that the progressive loss of limbic and neocortical ...Whether you’re caring for someone with Alzheimer’s disease or another dementia diagnosis, medication can help keep individuals calm and reduce their stress and anxiety. Let’s take a closer look at the different types of drugs that are used in Alzheimer’s care and other dementia cases. Preventing PainNon-drug approaches to changes in mood and behaviour. It is common for people with dementia to develop changes in mood and behaviour. In most cases, with the right person-centred care and support, these changes will pass. Non-drug approaches that should always be tried first. Read more.Aducanumab (marketed as Aduhelm) Information. Aduhelm is an amyloid beta-directed antibody indicated to treat Alzheimer’s disease. Aduhelm is approved under the accelerated approval pathway ... .